NOVA: Network Of Versatile Cell-Cell Communication Analysis

NOVA is a high-performance R package for predicting and visualizing cell-to-cell communication networks from single-cell and bulk transcriptomic data.

Details

NOVA uses connectomeDB2020, a manually curated ligand-receptor interaction database, to identify potential signaling interactions between cell types.

Key features:

• Seamless integration with Seurat V4 and V5

• Support for 21 species via HomoloGene mapping

• Multiple visualization options

• Differential communication analysis

• Parallel processing for large datasets

Main Functions

ExtractEdges

Extract ligand-receptor mediated interactions

DiffEdges

Compare communication between conditions

PlotHeatmap

Visualize communication as heatmap

PlotNetwork

Visualize communication as network

PlotChord

Generate chord diagram

PlotLRPairs

Visualize LR pairs between clusters

See also

• https://github.com/Zaoqu-Liu/NOVA

• Report bugs: https://github.com/Zaoqu-Liu/NOVA/issues

Author

Zaoqu Liu liuzaoqu@163.com