Calculate ligand p-values from the bootstrapped ligand activity analysis

calculate_p_value_bootstrap Calculate the p-value for each ligand from the bootstrapped ligand activity analysis

Usage

calculate_p_value_bootstrap(bootstrap_results, ligand_activities, metric = "aupr_corrected")

Arguments

bootstrap_results

Output of bootstrap_ligand_activity_analysis

ligand_activities

Output of predict_ligand_activities

metric

Metric to use (Default: "aupr_corrected")

Value

Data frame with the ligand name, the number of times the bootstrapped value had a higher score than the observed (total), and the p-value for each ligand, calculated as total/length(bootstrap_results)

Examples

if (FALSE) { # \dontrun{
permutations <- bootstrap_ligand_activity_analysis(expressed_genes_receiver, geneset_oi, background_expressed_genes,
  ligand_target_matrix, potential_ligands,
  n_iter = 10
)
p_values <- calculate_p_value_bootstrap(permutations, ligand_activities, metric = "aupr_corrected")
} # }