A dataset containing ligand-receptor pairs curated from the FANTOM5 project, converted to human gene symbols.
Format
A data frame with 2557 rows and 17 columns:
- Pair.Name
Unique identifier for the ligand-receptor pair
- Ligand.ApprovedSymbol
HGNC approved symbol for the ligand
- Ligand.Name
Full name of the ligand
- Receptor.ApprovedSymbol
HGNC approved symbol for the receptor
- Receptor.Name
Full name of the receptor
- DLRP
DLRP database reference
- HPMR
HPMR database reference
- IUPHAR
IUPHAR database reference
- HPRD
HPRD database reference
- STRING.binding
STRING binding evidence
- STRING.experiment
STRING experimental evidence
- HPMR.Ligand
HPMR ligand identifier
- HPMR.Receptor
HPMR receptor identifier
- PMID.Manual
PubMed ID for manual curation
- Pair.Source
Source classification: "known" or "novel"
- Pair.Evidence
Evidence level: "literature supported" or "putative"
- mode
Signaling mode/category of the interaction
Source
Ramilowski, J.A. et al. A draft network of ligand-receptor-mediated multicellular signalling in human. Nat Commun 6, 7866 (2015). doi:10.1038/ncomms8866