Ligand-Receptor Interaction Database

A data frame containing ligand-receptor pairs for cell-cell communication analysis.

Usage

database

Format

A data frame with columns:

Pair.Name

Name of the ligand-receptor pair

Ligand.ApprovedSymbol

Official gene symbol of the ligand

Ligand.Name

Full name of the ligand

Receptor.ApprovedSymbol

Official gene symbol of the receptor

Receptor.Name

Full name of the receptor

Classification

Type of interaction (e.g., Cytokine, Growth factor)

Source

Curated from multiple public databases including CellPhoneDB, CellChatDB, and literature.

Examples

data(database)
#> Warning: data set 'database' not found
head(database)
#>      Pair.Name Ligand.ApprovedSymbol                      Ligand.Name
#> 1     A2M_LRP1                   A2M            alpha-2-macroglobulin
#> 2 AANAT_MTNR1A                 AANAT aralkylamine N-acetyltransferase
#> 3 AANAT_MTNR1B                 AANAT aralkylamine N-acetyltransferase
#> 4    ACE_AGTR2                   ACE  angiotensin I converting enzyme
#> 5   ACE_BDKRB2                   ACE  angiotensin I converting enzyme
#> 6   ADAM10_AXL                ADAM10  ADAM metallopeptidase domain 10
#>   Receptor.ApprovedSymbol                                      Receptor.Name
#> 1                    LRP1 low density lipoprotein receptor-related protein 1
#> 2                  MTNR1A                              melatonin receptor 1A
#> 3                  MTNR1B                              melatonin receptor 1B
#> 4                   AGTR2                    angiotensin II receptor, type 2
#> 5                  BDKRB2                             bradykinin receptor B2
#> 6                     AXL                       AXL receptor tyrosine kinase
#>   Classification
#> 1          other
#> 2          other
#> 3          other
#> 4          other
#> 5          other
#> 6          other