Get Lactate Signaling Gene Sets

Source: R/lactate.R

Returns curated, literature-validated gene sets involved in lactate signaling pathways. Useful for pathway analysis, visualization, and validation.

Gene selection criteria:

  • Synthesis: LDHA family (excludes LDHB which prefers reverse reaction)

  • Export: MCT4 (SLC16A3) as primary exporter, plus other MCTs and BSG chaperone

  • Direct sensing: HCAR1 only (the sole confirmed lactate GPCR)

  • Indirect sensing: Classic proton-sensing GPCRs (GPR4, GPR65, GPR68, GPR132)

  • Uptake: MCT1 (SLC16A1) as primary importer, plus BSG chaperone

getLactateGenes(category = "all")

Arguments

category

Character. Gene category to return:

  • "all" (default): All gene sets

  • "production": Synthesis and export genes

  • "degradation": Lactate consumption enzymes

  • "direct_sensing": HCAR1 receptor

  • "indirect_sensing": Proton-sensing GPCRs

  • "uptake": Import transporters

Value

A named list of gene vectors. If category is "all", returns the complete nested list structure. Otherwise, returns the specific category.

Examples

# Get all gene sets
genes <- getLactateGenes()
names(genes)
#> [1] "production"       "degradation"      "direct_sensing"   "indirect_sensing"
#> [5] "uptake"          

# Get synthesis enzymes
genes$production$synthesis
#> [1] "LDHA"    "LDHC"    "LDHAL6A" "LDHAL6B"
# [1] "LDHA" "LDHC" "LDHAL6A" "LDHAL6B"

# Get proton-sensing receptors
genes$indirect_sensing$proton_receptors
#> [1] "GPR4"   "GPR65"  "GPR68"  "GPR132"
# [1] "GPR4" "GPR65" "GPR68" "GPR132"

# Get only production genes
prod_genes <- getLactateGenes("production")

# Get direct sensing receptor
getLactateGenes("direct_sensing")$receptor
#> [1] "HCAR1"
# [1] "HCAR1"