All functions

getProductionScores() getSensingScores() getCommunicationScores() getSignificantInteractions() getPathwayAggregated() getParameters()

Accessor Functions for scMetaLink Objects

aggregateByPathway()

Aggregate Communication by Pathway

checkLactateGenes()

Check Lactate Gene Availability

citationScMetaLink()

Show Package Citation

compareCommunication()

Compare Two Conditions

computeCommunication()

Compute Metabolite-Mediated Cell Communication

computeSpatialCommunication()

Compute Spatial Communication

crc_expr

CRC Example Expression Data

crc_meta

CRC Example Cell Metadata

createScMetaLink()

Create scMetaLink Object

createScMetaLinkFromSCE()

Create scMetaLink from SingleCellExperiment

createScMetaLinkFromSeurat()

Create scMetaLink from Seurat Object

createScMetaLinkFromSeuratSpatial()

Create scMetaLink from Seurat Spatial Object

createScMetaLinkFromSpatial()

Create scMetaLink Object from Spatial Data

enrichPathways()

Pathway Enrichment Analysis

exportResults()

Export Results to CSV

filterSignificantInteractions()

Filter Significant Interactions

getCommunicationMatrix()

Get Communication Summary Matrix

getDatabaseInfo()

Get Database Information

getLactateGenes()

Get Lactate Signaling Gene Sets

getLactateSignalingSummary()

Get Lactate Signaling Summary

getMetaboliteReceptors()

Get Receptors for a Metabolite

getPathwayCommunicationMatrix()

Get Pathway Communication Matrix

getPathwayMetaboliteNetwork()

Get Pathway-Metabolite Network

getPathwayMetabolites()

Get Metabolites in Pathway

getSpatialDistanceStats()

Get Spatial Distance Statistics

getSpatialLactateHotspots()

Get Spatial Lactate Hotspots

getSummaryStats()

Get Summary Statistics

getTopLactateProducers()

Get Top Lactate Producers

getTopLactateSensors()

Get Top Lactate Sensors

getTopProducers()

Get Top Producing Cell Types for a Metabolite

getTopSensors()

Get Top Sensing Cell Types for a Metabolite

identifyCellTypeSpecificMetabolites()

Identify Cell Type Specific Metabolites

identifyCommunicationHotspots()

Identify Communication Hotspots

inferLactateSignaling()

Infer Lactate-Mediated Cell Communication

inferProduction()

Infer Metabolite Production Potential

inferSensing()

Infer Metabolite Sensing Capability

inferSpatialLactateSignaling()

Infer Spatial Lactate Signaling

listGenes()

List Available Genes

listMetabolites()

List Available Metabolites

listTopPathways()

List Top Pathways

loadScMetaLink()

Load scMetaLink Object

metalinksdb

MetalinksDB Database

plotCommunicationCircle()

Plot Communication Circle

plotCommunicationHeatmap()

Plot Communication Heatmap

plotCommunicationNetwork()

Plot Communication Network

plotDifferentialCommunication()

Plot Differential Communication

plotEnrichedPathways()

Plot Enriched Pathways

plotLactatePathwayComparison()

Plot Lactate Pathway Comparison

plotLactateSignaling()

Plot Lactate Signaling Heatmap

plotMetaboliteProfile()

Plot Metabolite Profile

plotPathwayCommunication()

Plot Pathway Communication

plotSpatialCellTypes()

Plot Spatial Cell Types

plotSpatialCommunicationNetwork()

Plot Spatial Communication Network

plotSpatialComparison()

Plot Spatial Communication Comparison

plotSpatialDistanceDistribution()

Plot Spatial Distance Distribution

plotSpatialFeature()

Plot Spatial Communication Heatmap

plotSpatialHotspots()

Plot Spatial Hotspots

plotSpatialLactate()

Plot Spatial Lactate Signaling

plotTopInteractions()

Plot Top Interactions

runScMetaLink()

Run Complete scMetaLink Analysis

runScMetaLinkSeurat()

Run scMetaLink from Seurat Object

saveScMetaLink()

Save scMetaLink Object

show(<scMetaLink>)

scMetaLink Class Definition

scMetaLink scMetaLink-package

scMetaLink: Single-Cell Metabolite-Mediated Cell Communication Analysis

searchGene()

Search Gene in Database

searchMetabolite()

Search Metabolite in Database

st_expr

Colon Spatial Transcriptomics Expression Data

st_meta

Colon Spatial Transcriptomics Metadata

st_scalefactors

Colon Spatial Transcriptomics Scale Factors

summarizeCommunicationPairs()

Summarize Communication by Cell Type Pairs

summarizePathwayActivity()

Summarize Pathway Activity