Compute Drug Prioritization Score (Dr)

Calculate drug prioritization scores based on the ratio of sensitive and resistant tumor cell populations identified by scPharmIdentify.

Usage

scPharmDr(object)

Arguments

object: A Seurat object after running scPharmIdentify.

Value

A data frame with the following columns:

DRUG_ID: GDSC drug identifier
DRUG_NAME: Drug name
SENSI_RATIO: Proportion of sensitive tumor cells
RESIS_RATIO: Proportion of resistant tumor cells
Dr: Drug prioritization score
Rank: Drug ranking (1 = best)

Details

The Dr score is calculated as: $$Dr = S \times (1 - R)$$ where S is the proportion of sensitive cells and R is the proportion of resistant cells among tumor cells. Higher scores indicate better drug candidates for the patient.

Examples

if (FALSE) { # \dontrun{
# After running scPharmIdentify
dr_scores <- scPharmDr(result)
head(dr_scores)
} # }