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Fit GRN with bagging

Source: R/grn-inference.R
fit_grn_bagging.Rd

Fit GRN using Ridge regression with bootstrap aggregation (bagging) for more robust coefficient estimation.

Usage

fit_grn_bagging(
  gem,
  TFdict,
  alpha = 10,
  bagging_number = 20,
  sample_frac = 0.8,
  verbose = TRUE,
  n_jobs = -1
)

Arguments

gem

Gene expression matrix (cells x genes)

TFdict

TF-target dictionary

alpha

Regularization strength

bagging_number

Number of bootstrap iterations

sample_frac

Fraction of cells to sample in each iteration

verbose

Print progress

n_jobs

Number of parallel jobs (-1 for all cores)

Value

List with median coefficients and all bootstrap coefficients