Fit a gene regulatory network using Ridge regression. Returns a
coefficient matrix where entry (i,j) represents the regulatory effect
of gene i on gene j.
Usage
fit_grn_coef_matrix(gem, TFdict, alpha = 1, verbose = TRUE)
Arguments
- gem
Gene expression matrix (cells x genes)
- TFdict
Named list mapping target genes to regulator TFs
- alpha
Regularization strength for Ridge regression
- verbose
Print progress
Value
Coefficient matrix (genes x genes)